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The 2,2-dimethyl substitution pattern on this ring occupies a lipophilic sub-pocket between TM2 and TM3 that is highly conserved in the GLP-1 receptor but differs in related class B GPCRs such as the glucagon and GIP receptors
Except for linagliptin, which is eliminated via a biliary route, all other DPP-4 inhibitors are excreted in the urine (22, 29, 32, 33)
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