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They more often exhibit peripheral oedema, orthopnoea, a higher New York Heart Association (NYHA) functional class for HF and significantly reduced 6MWT distance
[1] [4] When to seek medical attention : Patients should contact their healthcare provider if they experience severe abdominal pain, persistent vomiting, signs of gallbladder disease, vision changes (prompt ophthalmology evaluation recommended), or symptoms of thyroid tumors (neck mass, difficulty swallowing, persistent hoarseness)
Vagal afferent neurons (VANs) expressing GLP-1Rs innervate intestinal mucosa and hepatic portal vasculature, suggesting these pathways may transduce peripheral GLP-1 RA effects to central satiety and glucoregulatory centers 57,58,59
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