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Adolescents: Later chronotypes in teenagers may allow a slightly extended dosing window (up to 1:00 or 2:00 PM), but this must be balanced against the well-documented relationship between stimulant use and delayed sleep phase in this age group [3]

Patients with higher CD4 + T cell infiltration had significantly shorter OS than those with lower infiltration ( Figure 2 3.1.1 Cancer-associated fibroblasts (CAFs) TME includes not only immune cells but also stromal cells, and CAFs are the main stromal cell type in the TME

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