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After you eat (and your blood sugar increases), GLP-1 medications work by helping your body make more insulin while secreting less glucagon
59 In that trial, 731 patients with HFpEF and BMI 30 kg/m 2 were randomised to receive tirzepatide or placebo for at least 52 weeks
74 In a comparative study in obese male mice of vertical sleeve gastrectomy (VSG), semaglutide treatment, and controls, both interventions improved glycemic control and reduced body weight, but VSG significantly decreased energy expenditure and induced notable bone loss, whereas semaglutide preserved BMD over six weeks
If it holds up in larger, biopsy-confirmed studies, hepatic steatosis could become one of the areas where triple agonism has the strongest differentiated rationale though, as with everything about this molecule, that remains to be confirmed in the full program
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