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BPC-157 is a synthetic pentadecapeptide (15 amino acids) derived from a sequence identified in gastric juice, whereas TB-500 is a synthetic fragment of thymosin beta-4 (T4), a naturally occurring protein involved in cell structure and motility so one is a short stand-alone peptide and the other a fragment modelled on a larger regulatory protein
In vitro studies indicate that hepatic resident macrophages detect elevated free fatty acids and respond by increasing TNF- secretion that, in turn, promotes the progression of steatosis in hepatocytes ( Metabolic burden in hepatocytes activates multiple cell death pathways, including apoptosis, necroptosis, pyroptosis, and ferroptosis, which can further amplify the inflammatory and fibrogenic response ( Figure 1B )
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