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The facilities built in the pre-GLP-1 era were designed for smaller-scale, batch-process synthesis of less complex molecules

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VIP is critical for preserving ENS function: VIP-deficient mice exhibit attenuated jejunal motility (Lelievre et al., 2007), and downregulated VIP expression correlates with severe constipation, indicating attenuated VIP signaling as a common pathological feature in dysmotility ( Escherichia coli (but not Lactobacillus ) restores its levels, suggesting specific microbial metabolites modulate VIP synthesis ( 4.3.3 Nitric oxide Nitric oxide (NO), a key inhibitory neurotransmitter, is synthesized by NOS via the catalysis of L-arginine