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Figure 2 Collectively, the above-discussed studies suggest that a clear comprehension of the contribution of genetic polymorphisms in folate-pathway genes to the maternal risk of birth of a child with DS should take into account the origin of the meiotic error and, possibly, the dietary habits and lifestyles of at least two generations, i.e., the mother and the maternal grandmother (Figure 2)

Of note, the dose of GLP-1(2836) used was selected on the basis of its dose response effect on post-IRI LVDP (Supplemental Figure 2)

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after reconstitution, refrigerate and use within 12 weeks