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In the same concentration range (0.360 M), intracellular NAD + increased approximately 1.2- to 1.6-fold, with 10 M reaching statistical significance (P 0.05), indicating that weight loss was not driven by appetite suppression
It is advisable to consult a doctor before starting treatment
Unlike full-length growth hormone, AOD-9604 does not stimulate IGF-1 production or interact with traditional growth hormone receptors, indicating an independent mechanism of action that has been the subject of ongoing investigation
The foundational obesity finding comes from Kraus and colleagues (Nature, 2014), who showed that knocking down NNMT protected mice against diet-induced obesity establishing NNMT as a metabolic target in the first place
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