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The placebo-adjusted weight loss is required by regulatory bodies to determine whether an investigational drug is efficacious and tolerable but does not provide sufficient information on the effect size in clinical practice, since it can never fully account for real-life variability
It can also help prevent cell apoptosis which helps maintain cell viability and contribute to overall mitochondrial function
A few patients may experience pain after injection of hydroxocobalamin
Why standard dosing ranges exist The 300-500mcg daily range did not appear arbitrarily
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