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& Terwindt, G
During spermatogenesis, sperm DNA is highly compacted and packaged with protamines, replacing histones to create a more condensed structure
Adequate levels help modulate immune activity rather than overstimulating it, which can be relevant for individuals managing chronic inflammatory conditions or autoimmune patterns
Conditional knockout of Hsp90 resulted in aberrant AR expression in spermatogonia, followed by extensive apoptosis of post-pachytene germ cells, complete arrest of spermatogenesis, and eventual testicular atrophy (Kajiwara et al., 2012)
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