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Receptor Pharmacology As a balanced tri-agonist, retatrutide is used as a tool compound to characterise relative receptor potency and downstream signalling compared with single- and dual-agonist references

1041 Derivation of a preference-based value set for the Short Warwick-Edinburgh Mental Well-being Scale (SWEMWBS) to allow calculation of Mental Well-being Adjusted Life Years (MWALYs) Hei Hang Edmund Yiu 1 , Stavros Petrou 2 , Sarah Stewart-Brown 3 , David Churchman 4 , Jason Madan 3 1 Department of Pharmacology and Pharmacy LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, 2 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK, 3 Warwick Medical School, University of Warwick, Warwick, UK, 4 InSpired Health Outcomes, Witne, UK Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :1041 Aims Concerns have been raised about the sensitivity of widely used preference-based instruments, such as the EQ-5D, in valuing mental health benefits

Some people use lower doses during breaks rather than complete discontinuation, but this strategy lacks clinical validation

Navigation should be coherent across the entire journey