Most strikingly, multiple trials have now shown that GLP-1 agonists can lead to the resolution of MASH, a severe form of fatty liver disease, without worsening of liver fibrosis, which is a common adverse outcome seen with some current medications
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Growth factors also affect tight junction formation: basic fibroblast growth factor (bFGF) enhances TJ density, whereas it is reduced by the vascular endothelial growth factor vascular endothelial growth factor (VEGF) (Morin-Brureau et al., 2011)