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During the first 12 to 16 weeks of treatment, many people experience a small, transient decline in estimated glomerular filtration rate (eGFR), which corresponds to a slight increase in serum creatinine

Hydration: Drink plenty of water to prevent dehydration and support kidney health

Table of Contents How Retatrutide Works and Its Effects on the Digestive System Acid Reflux as a Reported Side Effect of Retatrutide How Common Are Gastrointestinal Side Effects in Clinical Trials Managing Acid Reflux Symptoms Whilst Taking Retatrutide When to Seek Medical Advice About Digestive Symptoms What Current UK and International Guidelines Say Scientific References Frequently Asked Questions How Retatrutide Works and Its Effects on the Digestive System Retatrutide slows gastric emptying via GLP-1 receptor activation, which may increase the likelihood of acid reflux symptoms, though a definitive causal link between delayed gastric emptying and GORD has not been established

True GLP-1 drugs are peptide-based prescription injections that act on specific gut-brain receptors