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Clinical Implications SURMOUNT-5 provides the first randomized evidence that tirzepatide leads to greater reductions in body weight and waist circumference than semaglutide in people without diabetes
Interestingly, new research published in the journal Nature Medicine evaluated the health outcomes of more than 2 million veterans with diabetes taking a GLP-1 and found that while the medications had positive effects on several health conditions, like heart disease and substance use disorders, they were negatively associated with some, including arthritis
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GHRH (e.g., CJC-1295, Tesamorelin) stimulates pituitary somatotroph cells via the GHRH-R receptor, increasing the amplitude of each GH pulse
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