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In PD, pairing novel markers, such as seed amplification assays and extracellular vesicle cargo profiling, with specialized imaging modalities (e.g., neuromelanin-sensitive MRI, susceptibility-weighted imaging for iron deposition) has yielded superior diagnostic accuracy and staging resolution [603, 604]
We think this could lead to new interventions, such as reducing the glutathione overload through synthesis inhibitors or compounds that can dissipate it. The findings also have implications for potential therapies for lung cancers related to mutations in the KEAP1 gene
J Cereb Blood Flow Metab 33:15001513 Erahin M, zsavc D, ener A, zakpnar B, Toklu HZ, Akakin D, ener G, Yeen B (2013) Obestatin alleviates subarachnoid haemorrhage-induced oxidative injury in rats via its anti-apoptotic and antioxidant effects
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