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These symptoms often appear during the first few weeks of treatment or after a dose increase
It is a spectrum, a set of standards, and a discipline that separates serious researchers from those who are gambling with their work
Ceases release of glucagon (a hormone secreted by the alpha cells of the pancreatic islets of langerhans during hypoglycaemia)
FIGURE 1 Given the role of GLP-1 in glycaemic control, the anti-apoptotic, growth-stimulating and insulin secretion-promoting effects on pancreatic -cells, the ability to re-sensitize the cellular insulin-signaling, minor side effects, good tolerance by normoglycemic patients and the fact that GLP-1 does not desensitize, synthetic GLP-1R agonists have been on the market for decades to treat type 2 diabetes mellitus (T2DM) or, more recently, to improve weight loss (Drucker, 2018)
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