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Three major classes of sensors translate these signatures into downstream responses: calmodulins (CaM), Ca 2 -dependent protein kinases (CDPKs), and calcineurin B-like proteins (CBLs) (Tokas et al
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The 2014 Beck Phase 2 randomised controlled trial published in the International Journal of Colorectal Disease provides the clinical-research-stage data point (PMID 25331030)
The proposed mechanisms are angiogenic and cytoprotective
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