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Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis
Physician adoption is increasing rapidly and demand is accelerating as healthcare systems and private-pay markets broaden access, positioning these therapies as one of the most significant commercial opportunities in modern pharmaceuticals
Second, most evidence is derived from preclinical models, and large-scale clinical validation is required
In cell culture, 25 M applied for three to five days is the standard working concentration
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