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This article was written by Dr Edward Leatham, Consultant Cardiologist 2026 E.Leatham

No, immediate switching risks overlapping receptor stimulation and unexpected side effects

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GIPR antagonist, GIP(330)NH2, and GIP co-infusion in lean individuals prevented a fivefold increase in adipose tissue blood flow induced by GIP infusion alone ( Co-administration of triton-WR1339 infusion and D-Ala2-GIP injection 20 min following oil gavage in mice significantly increases TG accumulation in plasma at 60 and 90 min, and ApoB-48 levels at 90 min compared to PBS control (Hsieh et al., 2010), suggesting a role for GIP in plasma TG independent of triglyceride rich lipoprotein (TRL) clearance