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Relevance for Next-Generation GLP-1 and Peptide Therapeutics As GLP-1 therapies evolve toward dual- and multi-agonist peptides, formulation complexity is expected to increase

Next-generation sequencing, single-cell omics, spatial sequencing, proteomics, metabolomics, and microbiome profiling may together provide a more comprehensive view of resistance evolution

However, delivering FAs orally is challenging because they are absorbed before reaching the target site

The BMJ/MAGIC Group found that Asian, African, or Hispanic ethnicity was a risk factor for cardiovascular and renal outcomes and increased benefits of the medications, although race and ethnicity are social constructs that may not represent a genetic predisposition