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Patients should seek immediate medical attention for persistent vomiting or inability to keep fluids down for more than 24 hours, severe abdominal pain (especially if radiating to the back, which could indicate pancreatitis), or right upper quadrant pain with fever or yellowing of the skin (possible gallbladder issues)all rare but serious potential complications
Since I was also having some major issues with low energy and mood, the Dr who helped me get through my original no estrogen issue suggested giving B12 shots a try
This has been reported with both tirzepatide and retatrutide, though it is likely related to the weight loss itself rather than the medication directly
Stoppani also notes it's often best taken with food especially a meal containing carbs since research suggests carbs can help drive uptake into muscle
