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Standard cycle: 4 weeks active, 2 to 4 weeks rest Extended cycle (under physician guidance): 6 to 8 weeks active, 4 weeks rest Signals to resume: Rest period complete, no lingering side effects, healing goals not yet fully achieved Signals to stop: Persistent side effects, goal achieved, or physician advises discontinuation Most users complete two to three full cycles for injury recovery

Second Nature doesnt currently accept people with CKD onto its medication-supported programme because the level of monitoring required exceeds what the programme can provide

Plausible mechanisms: Dehydration from GI losses and reduced chewing are directly reasonable and backed by general physiology