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Research indicates that collagen production decreases by approximately 1% per year after age 20, compounding over decades into visible sagging
[13] In a newly diagnosed vitamin B 12 -deficient patient, normally defined as when serum levels are less than 200 pg/ml, daily IM injections of hydroxocobalamin up to 1,000 g (1 mg) per day are given to replenish the body's depleted cobalamin stores
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