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It is not because the semaglutide itself is different at the molecular level
Aleniglipron's ACCESS Phase 2b data is numerically impressive (11.3% placebo-adjusted at 120 mg in 36 weeks, and up to 15.3% at 240 mg), suggesting it may match or exceed orforglipron's ATTAIN-1 results (12.4% mean at 72 weeks)
They can cause significant muscle loss along with fat loss, which some research suggests may be as high as 30-40% of total weight lost
Dual agonism at the GLP-1 and glucagon receptors
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