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The mechanism is only partially understood but involves reduction of gene and protein expressions of fibrotic and inflammatory markers such as TGF-, TNF-, IL-2, MMP-9, vimentin and enhancement of antioxidant ability by increment of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and by preservation of mitochondrial function [215]
Therapeutic potential of honey and propolis on ocular disease
Side effects can include nausea, constipation, dizziness, and an increased risk of mood changes or suicidal thoughts, particularly in individuals with a history of depression or psychiatric illness
1012 Whereas, photo-aging (exposure to ultra-violet light) and chronologically aged skin are involved in a cascade of cellular and molecular signaling mechanisms (mainly due to oxidative stress)
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