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Association Analysis of the SLC22A11 (Organic Anion Transporter 4) and SLC22A12 (Urate Transporter 1) Urate Transporter Locus with Gout in New Zealand Case-Control Sample Sets Reveals Multiple Ancestral-specific Effects

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5 This concept, called polypharmacology, describes drugs having multiple functions

We have postulated (15) that increased breakdown of cholesterol esters from VLDL + LDL as a consequence of L-carnitine-induced catabolism of fatty acids, combined with transfer of cholesterol esters from VLDL + LDL to HDL, probably mediated by cholesteryl ester transfer protein 33, 34 , leads to increased cholesterol reverse transport and excretion 35, 36