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Its an opportunity for manufacturers to become more responsive to patients and to better control their pricing. SHORTAGES AND SPECIALTY As the demand for GLP-1 therapies has exploded, powered by dramatic weight loss results reported in clinical trials and in the real world by celebrity influencers, the result has been supply shortages that are expected to persist into next year
5.2 Therapeutic efficacy in animal models 5.2.1 Neurodegenerative disorders Several compounds have demonstrated significant therapeutic potential in animal models of neurodegenerative diseases, such as AD and PD (Wang et al., 2022)
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Variants of OXM resistant to DPP-IV (achieved by addition of PEG [86], fatty acids [87], substitution of certain amino acids [85] or even combined modifications [88]) have been advanced to circumvent the limited clinical potential of the native peptide
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