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Description

The docking energy between LAT1 and LAAM GSH-CQDs was four times lower than that of LAAM TC-CQDs, and the binding affinity between LAT1 and LAAM GSH-CQDs was nearly three times higher than that of LAAM TC-CQDs, which is the inverse ratio of the measured K m

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This results in reduced secretion of M1-type cytokines (TNF-, IL-1, IL-6) and enhanced expression of M2-type cytokines such as Arginase-1 (Arg-1) and IL-10 via Nrf2 signaling (106), suggesting an immunoregulatory role in the ischemic brain

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However, in our experiment, even a 2-month repeated injection protocol did not appear to activate the Nrf2 pathway in healthy animals

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Fasting is not required

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