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Otro estudio clinico randomizado utilizando Metformina o placebo en DM1 adolescentes con sobrepeso y obesidad28 que reclut 140 nios, con una duracin de 26 semanas, tampoco observ una reduccin significativa de HbA1c a las 13 semanas23, pero si demostr reduccin en la DDT de insulina a favor del grupo de metformina as como una disminucin mayor al 10% del IMC en 24% de los tratados vs solo 7% del grupo placebo (p= 0.01)
Patients should be advised to stop semaglutide immediately and seek urgent medical attention if they experience severe or persistent abdominal pain (particularly if radiating to the back), jaundice, dark urine, pale stools, or other signs suggestive of pancreatitis or biliary complications
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