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Sustained weight loss was maintained over extended treatment durations of up to 104 weeks in STEP 5 [40], while efficacy was also consistent across ethnically diverse populations, as demonstrated in STEP 6 [41] and STEP 7 [43]
Serious but rare side effects include pancreatitis, gallbladder disease, gastroparesis, and thyroid C-cell tumour risk, the last of which is reflected in the medications boxed warning based on findings in animal studies
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Meanwhile, ginsenoside Rg3 significantly increased glutathione S-transferase 2 (GSTA2) protein expressionand activated the transcription of GSTA2 downstream of multiple cellular signaling pathways, including protein kinase A (PKA), PI3K and JNK (Gum and Cho, 2013b)
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