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extract has a protective effect on gentamicin-induced ototoxicity in Wistar albino rats and can reduce the level of cochlear ROS [220], and it can also reverse the 4-hydroxynonenal (4-HNE, a representative substance in cellular lipid peroxidation), inhibits the expression of protein phosphatase 1 nuclear targeting subunit (PNUTS), p53 and cas-3, and promotes the decreased expression of protein phosphatase1 (PP1) and MDM2 (oncogene) in the cochlea [221]
Presented for research literature review only Evans AM et al
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