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if that is done then a low dose maintenance is all we would need
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The crude viral lysate was initially concentrated by a brief two-tier CsCl gradient centrifugation for 3 h and then the vector fraction was dialyzed in MHA buffer (3.3 mM morpholinoethanesulfonic acid [MES], 3.3 mM HEPES [pH 7.5], 3.3 mM sodium acetate)
But this is modest compared to the 15% body weight reduction seen with 2.4 mg weekly injectable semaglutide in obesity trials
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