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On the basis of results of the most recent CVOTs (DAPA-HF, DAPA-CKD, EMPEROR-R), the FDA has approved dapagliflozin (2020) and empagliflozin (2021) to reduce risk for CV death and HF hospitalization in adults with HF and reduced ejection fraction regardless of whether they have diabetes [24, 25]
It's available with a prescription for adults with a BMI of 30 or above, or a BMI of 27 or above alongside a weight-related health condition like high cholesterol or high blood pressure
Lipoic acid prevents high-fat diet-induced hepatic steatosis in Goto Kakizaki rats by reducing oxidative stress through Nrf2 activation
What this means in practical terms: the clinical weight loss data you may see cited in the media is largely based on FDA-approved injectable or oral tablet formulations
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