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& Ray, K

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In the orthotopic lung tumor model, we observed a tendency for Fsp1 KO tumors to grow more quickly with daily LIP1 administration (Extended Data Fig

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Protocol Notes In the mouse trial q48h pulsed model over ~3 weeks and 11 total pulses, the first several injections (roughly the first 56 doses) likely do most of the meaningful work: they trigger apoptosis in the bulk of the senescent cell population, allow immune clearance of apoptotic debris, and sharply reduce SASP signaling

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