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When he reached the tirzepatide 15 mg weekly dose, he developed allodynia described as a "burning sensation all over his body." This case is important for two reasons

In a recent study, Liskiewicz and colleagues discovered that long-acting GIP receptor agonists activate GABAergic neurons that express the GIP receptor in the area postrema, and that GIP receptor signaling in GABAergic neurons is necessary for the effects of GIP to lower body weight [151]

The medications are not interchangeable milligram-for-milligram

Furthermore, liraglutide treatment drove osteogenic differentiation in human adipose-derived stem cells, human periodontal ligament cells, and dental pulp stem cells [49,50,51,52]