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Abstract Pathogenic variants in one allele of the KAT6A gene encoding the histone acetyltransferase KAT6A (MOZ, MYST3) cause ArboledaTham syndrome (ARTHS), characterised by developmental delay, cognitive impairment, and autism-like behaviours

The accumulation of lipid peroxides leads to oxidative damage of cell membranes, disrupting their structural and functional integrity, and serves as an important initiating step in promoting ICD

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Since its first reports by the Tor Vergata University of Rome, 65 numerous preclinical studies have shown that NBDHEX exerts high GST-inhibitory activity across a wide range of tumor types