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Patients included in the trial had HbA1c 7-10% and were treated with either: diet and exercise alone or 1 to 3 oral antidiabetic drugs (metformin, sulfonylurea, glitazone or sodium-glucose co-transporter 2 inhibitor)
Early trials of adjunctive therapies The first GLP-1 receptor agonist, Byetta (exenatide), was approved in the early 2000s
Despite adverse effects of increased urination, increased genital mycotic infections (in women more often than in men), and increased urinary tract infections, sodium-glucose cotransporter 2 inhibitors are associated with minimal hypoglycemia
It's also naturally found in foods, especially animal products like beef, poultry, and dairy, and available as a dietary supplement where it's sold alone or alongside other ingredients intended to support fat loss or increase exercise performance
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