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The clinical incidence is low

[35] In rodent pre-clinical studies, urinary and serum alpha GST have been shown to be sensitive and specific indicators of renal proximal tubular and hepatocyte necrosis respectively

In girls with TS, p53 signaling was associated with carriage of the G allele of the rs2069502 CDK4 SNP (including a +1.5-fold increase in MDM2 expression, implying a repression of P53 function, 27 and a +1.5-fold increase in ATM expression, implying that DNA damage increased activation of P53

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