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Brown DA, London E

Constipation is one of several GI side effects linked to GLP-1 receptor agonists, and some research shows that its especially common with semaglutide, the active ingredient in both Ozempic (for Type 2 diabetes) and Wegovy (for weight management)

For instance, it isnt clear if the peptide binds to a cell surface receptor to produce its effects or if it is transported into the cell and perhaps has effects directly at the level of the DNA

APS could activate the nuclear erythroid-derived 2-related factor 2 (NRF2) pathway and its downstream protein glutamate-cysteine ligase and heme oxygenase-1 (HO-1) to anticipate anti-oxidative stress, reversing the marker enzyme of peroxidase catalase, MDA, SOD, and GSH-Px after suffering OS damage (Yan Y