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Landmark clinical trials published since 2021, such as those investigating the effects of semaglutide and dulaglutide, have demonstrated a reduction in major adverse cardiovascular events (MACE) and a slowing of the progression of chronic kidney disease in patients with type 2 diabetes
Another peptide hormone that is similar to IGF-1 is called IGF-2
Oxidative stress markers: Elevated levels of methylglyoxal (MG) and decreased superoxide dismutase (SOD) activity are associated with DPN, reflecting increased oxidative stress
Initial glucose-lowering effects typically occur within days to weeks, but maximum benefits including HbA1c reduction and cardiovascular effects may take up to 3 months to fully manifest
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