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doi:10.1007/s00192-007-0515-5 Nickel JC, Moldwin R, Lee S, Davis EL, Henry RA, Wyllie MG
PMC 7657338
Diabetic kidney disease, a common complication in patients with type 2 diabetes mellitus, is associated with a markedly increased morbidity and mortality, especially of cardiovascular origin, and faster progression to end-stage renal disease
Receptor stimulation reduces ADSC production of protective cytokines, promotes reactive oxygen species (ROS) production causing oxidative damage to fibroblasts, and reduces glucose uptake by ADSCs leading to decreased ATP production and apoptosis
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