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The GLP-1RAs group had a lower rate of adverse CVEs, including new-onset heart failure (HR 0.88

and our targeted LCMS data demonstrate a profound change in broad metabolic activity in cells, supported by RNA-seq analysis of metabolic gene expression changes

Moreover, the addition of finerenone to this combination therapy could potentially provide stronger cardiorenal protective benefits

J Pharmaceut Sci 109:15471557 Mccartney F, Gleeson JP, Brayden DJ (2016) Safety concerns over the use of intestinal permeation enhancers: a mini-review, Tissue barriers 4:e1176822 Moreno-Prez O, et al (2024) Real-world effectiveness and safety of oral semaglutide in people living with type 2 diabetes: a nationwide multicentre retrospective observational study (ENDO2S-RWD)