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For instance, selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed antidepressants, carry a black-box warning for increased suicidal risk, and frequently cause sexual dysfunction in up to 80% of female patients (Fornaro et al., 2019
A therapeutic peptide is chemically indistinguishable from dietary protein to these enzymes, so most of an oral dose is fragmented into inactive pieces before it can ever be absorbed
Liver Res 1(1):4253
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