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Building on the Therapy of the Past to Protect the Kidney: Combination of SGLT2i vs nsMRAs and GLP1-RAs for Diabetic Nephropathy There has been much improvement in slowing progressive loss of kidney function over time (Table 4)

Gastrointestinal effects such as nausea, diarrhoea, vomiting and constipation are the most consistently reported side effects, and they tend to occur more frequently at higher doses

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[15] [14] While mild gastrointestinal symptoms are common and often transient with GLP-1 therapy, certain warning signs warrant prompt medical evaluation