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The jump from 10mg to 15mg added only 1.4 percentage points

Macaulay et al., 2022

Effects of sevoflurane pretreatment on the apoptosis of rat H9c2 cardiomyocytes and the expression of GRP78

RESEARCH AREAS Estrogen-related receptor alpha (ERR) agonism and receptor binding characterization Transcriptional regulation of mitochondrial biogenesis pathways (e.g., PGC-1 coactivation networks) Oxidative phosphorylation and fatty-acid oxidation gene-expression signaling Cellular energy-metabolism and substrate-utilization pathway modeling WHAT RESEARCHERS LOOK AT Receptor-binding and reporter-gene assays measuring ERR isoform engagement Dose-response transcriptional profiling of metabolic target genes in cell culture Mitochondrial density and respiration assays in isolated model systems Pathway-selectivity and off-target screening across nuclear-receptor panels QUICK SPECS Form: Capsule not for ingestion Net per capsule: 100mcg Count: 100 capsules per bottle Purity: 98% (HPLC) Identity: Confirmed by HPLC/MS Storage: Store sealed, cool, dry, protected from light IDENTITY BASICS Type: Synthetic small-molecule ERR agonist (non-peptide) Molecular formula: CHNO Molecular weight: ~445.5 g/mol CAS: 2231747-31-0 SELECTED RESEARCH PubChem: SLU-PP-332 compound record PubMed: SLU-PP-332 literature index PubMed: ERR agonist research PubMed: ERR/mitochondrial biogenesis signaling DISCLAIMER For laboratory and in vitro research use only