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During short-term clinical trials in patients with benign prostatic hyperplasia (BPH) or both BPH and erectile dysfunction, the following centrally-mediated effects occurred in at least 1% of tadalafil-treated patients and more frequently than in placebo-treated patients: headache (4.1% vs 2.3%) and dizziness (1% vs 0.5%)
Reports indicate multiple companies preparing launches immediately after expiry, which historically results in rapid price resets and accelerated patient access
Other combinations of entero-pancreatic hormones including cagrisema (GLP-1/amylin RA) and the triple agonist retatrutide (GLP-1/GIP/glucagon RA) have also progressed to phase 3 trials as obesity treatments and early data suggests that may lead to even greater WL than tirzepatide
However, in Harmony Outcomes, albiglutide reduced the risk of MACE by 22%, with 0.52% and 0.83 kg reductions in HbA1c and weight, respectively, compared with those in the placebo group [18]
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