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Following treatment of HuOCSCs with the ferroptosis agonist erastin combined with anisomycin, the growth inhibition rate over time was significantly higher than that of the cells in the anisomycin alone and erastin alone groups (Figure 1A)

Key molecular mechanisms include mitochondrial reverse electron transport activation induced by mutant proto-oncogenes KRAS/BRAF [385], oxidative inactivation of DNA repair enzymes leading to mutation accumulation [386], and constitutive activation of NRF2 pathway [387]

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While the ADA recommends considering a GLP-1 receptor agonist or the addition of mealtime insulin, 3 the AACE/ACE algorithm additionally recommends SGLT-2 inhibitors and DPP-4 inhibitors as potential therapies that can be added to basal insulin, if they are not already incorporated into the medication regimen