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MOTS-c is a mitochondrial-derived peptide that activates AMPK through direct mitochondrial signaling and nuclear translocation under metabolic stress, whereas metformin activates AMPK indirectly by inhibiting Complex I of the mitochondrial electron transport chain, and AICAR mimics AMP to trick the cell into AMPK activation
McKetin R, Dean OM, Baker AL, Carter G, Turner A, Kelly PJ, et al
You can easily and safely self-inject at home with instruction from your physicians office
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