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In fact, one study found that peoples bodies absorbed about 49% of a 1-mcg dose of cyanocobalamin, compared to 44% of the same dose of methylcobalamin ( Conversely, another study comparing the two forms reported that about three times as much cyanocobalamin was excreted through urine, indicating that methylcobalamin may be retained better within your body ( However, some research suggests that differences in bioavailability between the two forms may be insignificant and that absorption could be influenced by factors such as age and genetics ( Unfortunately, recent research directly comparing these two forms of vitamin B12 is limited
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It can be used preoperatively or during severe trauma/illness in patients with low adrenocortical reserve, and in shock states unresponsive to fluids (when adrenal insufficiency is suspected)
[3] Deficiency of vitamin B leads to impaired function of PLP-dependent enzymes, which can manifest as neurological, hematological, and dermatological symptoms
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