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This dual action of tirzepatide potentially offers broader benefits, particularly in weight management and glycemic control, compared to semaglutide's singular focus
Beertsen, W
The post says clinical evidence in IBS populations remains limited and that most research focuses on weight management and diabetes rather than gastrointestinal disorders
The main mechanism of action of these GLP-1RA is the stimulation of the GLP-1R that triggers the activation of several metabolic pathways involved in insulin secretion, lipid metabolism, energy expenditure, pro-survival and anti-apoptotic cellular signaling, and oxidative stress prevention, in several tissues like the pancreas, central nervous system, heart, muscle, kidneys, gut, among others (15)
